How Alzheimer's disease affects decision-making in mice
Official title: Decision-making alterations in mouse models of Alzheimer's disease
Funded at University of Minnesota · NIH-11052655 · Data updated 2026-11-12
This study looks at how Alzheimer's disease affects the way mice make decisions, especially as they get older and considering their gender, to find ways that might help improve decision-making skills in people with Alzheimer's.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Minnesota NIH-funded |
| Lab location | 1 site (Minneapolis, United States) |
| Project start | March 1, 2021 |
| Project end | February 28, 2026 |
| Funding year | 2025 |
| Award (this year) | $587,479 |
| NIH project number | 5R01AG070296-03 |
| Project ID | NIH-11052655 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are older adults, particularly those aged 65 and above, who are experiencing cognitive decline or have been diagnosed with Alzheimer's disease.
✕Less likely to help
Patients under the age of 65 or those without cognitive impairments related to Alzheimer's disease may not benefit from this research.
What this research studies
This research investigates how Alzheimer's disease alters decision-making processes in mouse models, focusing on the impact of age and sex on these changes. By utilizing advanced neuroscience techniques, the study aims to understand the mechanisms behind poor decision-making in older adults, particularly those with Alzheimer's. The researchers will explore how specific interventions might improve decision-making abilities in these models, providing insights that could translate to human patients. The findings could help identify potential therapeutic strategies to enhance cognitive function in aging populations.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve decision-making abilities in older adults with Alzheimer's disease.
How similar studies have gone: Previous research has shown promising results in understanding cognitive decline in aging populations, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Minnesota
Minneapolis, United States Active
Researchers
- Principal investigator: Thomas, Mark John — University of Minnesota
- Study coordinator: Thomas, Mark John
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How Decision Making Changes in Early Alzheimer's Disease
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.