How allergic responses affect the body's ability to fight viruses
Mechanisms of IgE-mediated regulation of monocyte antiviral response pathways
This study is looking at how allergies can make it harder for your body to fight off viruses, especially by affecting certain immune cells, and it hopes to find new ways to help people with allergies who get sick from viruses.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project ID | NIH-11238160 on NIH RePORTER |
What this research studies
This research investigates the ways in which allergic reactions, specifically those mediated by IgE, can impair the body's antiviral responses, particularly in monocytes, which are a type of immune cell. The study aims to uncover the molecular mechanisms behind this impairment by using advanced techniques such as flow cytometry and transcriptomics to analyze how IgE signaling affects antiviral recognition and interferon receptor signaling. By understanding these processes, the research seeks to identify potential new treatments for patients suffering from allergic diseases that are exacerbated by viral infections.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with allergic conditions such as allergic asthma, atopic dermatitis, or allergic rhinitis, particularly those who experience exacerbations during viral infections.
Not a fit: Patients without allergic conditions or those who do not experience viral infections as a trigger for their symptoms may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for managing allergic diseases and improving antiviral responses in affected patients.
How similar studies have performed: While the specific mechanisms being investigated may be novel, previous research has established a link between viral infections and exacerbations of allergic diseases, suggesting that this area of study holds significant promise.
Where this research is happening
Rochester, United States
- University of Rochester — Rochester, United States (Active)
Researchers
- Principal investigator: Rowe, Regina Kay — University of Rochester
- Study coordinator: Rowe, Regina Kay
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.