How allergic responses affect the body's ability to fight viruses
Mechanisms of IgE-mediated regulation of monocyte antiviral response pathways
['FUNDING_CAREER'] · UNIVERSITY OF ROCHESTER · NIH-11091555
This study is looking at how allergies can make it harder for your body to fight off viruses, especially by affecting certain immune cells, and it's aimed at helping people with allergies who get sick more easily from viral infections.
Quick facts
| Phase | ['FUNDING_CAREER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF ROCHESTER (nih funded) |
| Locations | 1 site (ROCHESTER, UNITED STATES) |
| Trial ID | NIH-11091555 on ClinicalTrials.gov |
What this research studies
This research investigates how allergic reactions, particularly those mediated by IgE, can impair the body's antiviral responses, especially in immune cells called monocytes. By examining the molecular mechanisms involved, the study aims to understand how these allergic signals disrupt the body's ability to recognize and respond to viral infections. The researchers will use advanced techniques such as flow cytometry and transcriptomics to analyze the effects of IgE on antiviral pathways. This work is crucial for developing new treatments for patients suffering from allergic diseases that are exacerbated by viral infections.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals suffering from allergic conditions such as allergic asthma, atopic dermatitis, or allergic rhinitis.
Not a fit: Patients without allergic conditions or those not experiencing exacerbations due to viral infections may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that improve antiviral responses in patients with allergic diseases.
How similar studies have performed: While the specific mechanisms of IgE's impact on antiviral responses are not extensively studied, related research has shown that understanding immune interactions can lead to significant advancements in treatment.
Where this research is happening
ROCHESTER, UNITED STATES
- UNIVERSITY OF ROCHESTER — ROCHESTER, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ROWE, REGINA KAY — UNIVERSITY OF ROCHESTER
- Study coordinator: ROWE, REGINA KAY
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: allergic airway disease, Allergic Disease