How aldosterone affects blood flow in small brain vessels
Official title: Aldosterone-Vascular Signaling on Cerebral Small Vessel Function
Funded at University of Vermont & St Agric College · NIH-11029004 · Data updated 2026-11-12
This study is looking at how a hormone called aldosterone affects tiny blood vessels in the brain, which are important for keeping our thinking sharp, and it aims to find out if too much of this hormone could lead to problems like dementia, with hopes of discovering new ways to help people with cognitive issues.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Vermont & St Agric College NIH-funded |
| Lab location | 1 site (Burlington, United States) |
| Project start | January 8, 2025 |
| Project end | December 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $623,651 |
| NIH project number | 1R01NS140868-01 |
| Project ID | NIH-11029004 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals experiencing cognitive decline or those at risk for vascular cognitive impairment due to conditions like high blood pressure or hormonal imbalances.
✕Less likely to help
Patients with cognitive impairment not related to vascular issues or those with other unrelated neurological conditions may not benefit from this research.
What this research studies
This research investigates the role of aldosterone, a hormone, in the function of small blood vessels in the brain, which are crucial for maintaining cognitive health. The study focuses on understanding how excess aldosterone can lead to dysfunction in these vessels, potentially contributing to conditions like dementia. By using specialized mouse models, researchers will explore the mechanisms by which aldosterone affects blood flow and nutrient delivery to brain cells. The findings could provide insights into new treatment strategies for vascular cognitive impairment.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that improve blood flow in the brain and help prevent or treat dementia.
How similar studies have gone: Previous research has shown promising results in understanding the vascular contributions to cognitive impairment, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Vermont & St Agric College
Burlington, United States Active
Researchers
- Principal investigator: Koide, Masayo — University of Vermont & St Agric College
- Study coordinator: Koide, Masayo
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.