How alcohol use affects gut health in people with HIV
Gut Microbiota-Mediated Inflammatory Interactions Between Alcohol Use Disorders and HIV Infection
This study is looking at how drinking alcohol affects gut health and inflammation in people living with HIV, and it’s testing whether taking prebiotics can help improve gut health and reduce inflammation for those individuals.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rush University Medical Center NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project ID | NIH-10934375 on NIH RePORTER |
What this research studies
This research investigates the relationship between alcohol use disorder and inflammation in individuals living with HIV. It focuses on how alcohol impacts gut microbiota and intestinal barrier integrity, potentially worsening inflammation. The study explores the use of prebiotics that promote beneficial gut bacteria to enhance gut health and reduce inflammation in these patients. By examining the gut's response to alcohol in the context of HIV, the research aims to identify effective interventions.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals living with HIV who also have alcohol use disorder.
Not a fit: Patients who do not have HIV or alcohol use disorder may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved gut health and reduced inflammation for patients with HIV who also struggle with alcohol use disorder.
How similar studies have performed: Other research has shown promising results in using prebiotics to improve gut health, suggesting this approach may be effective.
Where this research is happening
Chicago, United States
- Rush University Medical Center — Chicago, United States (Active)
Researchers
- Principal investigator: Keshavarzian, Ali — Rush University Medical Center
- Study coordinator: Keshavarzian, Ali
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.