How alcohol and e-cigarettes harm brain and lung barriers
Injury of blood brain and alveolar-endothelial barriers caused by alcohol and electronic cigarettes via purinergic receptor signaling
['FUNDING_R01'] · TEMPLE UNIV OF THE COMMONWEALTH · NIH-11088852
This project explores how using alcohol and electronic cigarettes together might damage important protective barriers in the brain and lungs.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | TEMPLE UNIV OF THE COMMONWEALTH (nih funded) |
| Locations | 1 site (PHILADELPHIA, UNITED STATES) |
| Trial ID | NIH-11088852 on ClinicalTrials.gov |
What this research studies
We know that alcohol and smoking can individually harm the protective barriers in your lungs and brain. This project looks at what happens when people use both alcohol and e-cigarettes, which is not well understood. We are using advanced lab models and animal studies to see how these substances affect these barriers and how they might lead to brain and lung problems. Our goal is to uncover the specific ways these substances cause damage, focusing on a particular signaling pathway.
Who could benefit from this research
Good fit: This foundational research is relevant to individuals who use alcohol and electronic cigarettes and are concerned about their brain and lung health.
Not a fit: Patients not using alcohol or electronic cigarettes would not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to new ways to prevent or treat brain and lung damage caused by alcohol and e-cigarette use.
How similar studies have performed: While individual effects of alcohol and smoking are known, the combined impact of alcohol and e-cigarettes on these specific barriers is a relatively new area of focus.
Where this research is happening
PHILADELPHIA, UNITED STATES
- TEMPLE UNIV OF THE COMMONWEALTH — PHILADELPHIA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: PERSIDSKY, YURI — TEMPLE UNIV OF THE COMMONWEALTH
- Study coordinator: PERSIDSKY, YURI
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acquired brain injury