How alcohol affects TB risk and lung health in people living with HIV
Official title: The International URBAN Alcohol Research Collaboration on HIV/AIDS (ARCH) Center
Funded at Boston Medical Center · NIH-11405066 · Data updated 2026-11-12
This program looks at how drinking alcohol changes the chance of getting TB, developing TB after preventive therapy, and long-term lung problems for people living with HIV.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston Medical Center NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | September 10, 2021 |
| Project end | August 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $335,921 |
| NIH project number | 3P01AA029541-05S1 |
| Project ID | NIH-11405066 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults living with HIV—especially those who drink alcohol, have latent TB, or have completed TB treatment—are the ideal candidates for participation.
✕Less likely to help
People without HIV, those who do not drink alcohol, or individuals outside the study locations are unlikely to benefit directly from this project.
What this research studies
This international effort links teams in Uganda, Russia, and Boston to study alcohol use and its impacts on TB and lung health among people living with HIV. Researchers will follow adults with HIV over time, gather alcohol-use histories, test for new TB infections, and track outcomes after TB preventive therapy and TB treatment. The work combines medical exams, lab tests, and patient interviews to connect drinking patterns with TB acquisition, recurrence after preventive therapy, and post-TB lung disease. Results are meant to guide better prevention and care for people with HIV who drink alcohol.
Why it matters
Potential benefit: If successful, the work could lead to better ways to prevent TB and protect lung health for people living with HIV who drink alcohol.
How similar studies have gone: Previous studies have linked heavy alcohol use to higher TB risk and worse outcomes, but this coordinated international approach to TB acquisition, post-TPT disease, and post-TB lung health is relatively novel.
Where this research is happening
-
Boston Medical Center
Boston, United States Active
Researchers
- Principal investigator: Samet, Jeffrey H. — Boston Medical Center
- Study coordinator: Samet, Jeffrey H.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.