How alcohol affects liver cell signaling and health
Official title: Alcohol Metabolism Disrupts Hepatic Thiol Redox Signaling and Control
Funded at University of Colorado Denver · NIH-11012407 · Data updated 2026-11-12
This study looks at how drinking alcohol can harm your liver by affecting the way liver cells work, and it hopes to find new ways to help people with liver problems caused by alcohol.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado Denver NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project start | February 25, 2023 |
| Project end | January 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $414,539 |
| NIH project number | 5R01AA030024-03 |
| Project ID | NIH-11012407 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with a history of alcohol use or those diagnosed with alcohol-related liver disease.
✕Less likely to help
Patients who do not consume alcohol or have no liver-related health issues may not benefit from this research.
What this research studies
This research investigates the biochemical mechanisms by which alcohol consumption leads to liver damage and disease. It focuses on how chronic alcohol metabolism disrupts cellular pathways and affects redox signaling in liver cells, which is crucial for maintaining cellular health. By examining the relationship between alcohol metabolism, protein modifications, and oxidative stress, the study aims to uncover new insights into the pathogenesis of alcohol-related liver disease. Patients may benefit from a better understanding of how alcohol impacts liver function and potential new therapeutic targets.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments and prevention strategies for alcohol-related liver diseases.
How similar studies have gone: Previous research has shown promising results in understanding the biochemical effects of alcohol on liver health, indicating that this approach has potential for significant findings.
Where this research is happening
-
University of Colorado Denver
Aurora, United States Active
Researchers
- Principal investigator: Fritz, Kristofer S — University of Colorado Denver
- Study coordinator: Fritz, Kristofer S
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.