How alcohol affects insulin sensitivity in muscles of people with HIV
Alcohol-induced Skeletal Muscle Insulin Insensitivity in SIV/HIV: Myotube-derived Extracellular Vesicle-mediated Mechanisms
['FUNDING_FELLOWSHIP'] · LSU HEALTH SCIENCES CENTER · NIH-10884437
This study looks at how drinking a lot of alcohol over time affects how well muscles use insulin in people living with HIV, helping us understand how this might lead to health problems related to sugar levels.
Quick facts
| Phase | ['FUNDING_FELLOWSHIP'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | LSU HEALTH SCIENCES CENTER (nih funded) |
| Locations | 1 site (NEW ORLEANS, UNITED STATES) |
| Trial ID | NIH-10884437 on ClinicalTrials.gov |
What this research studies
This research investigates the impact of chronic binge alcohol consumption on insulin sensitivity in skeletal muscle among individuals living with HIV. Using a preclinical model, the study aims to understand the mechanisms by which alcohol disrupts insulin signaling pathways, potentially leading to metabolic issues. The research focuses on how these changes in muscle function can affect glucose uptake, which is crucial for managing health in people with HIV. By examining myotube-derived extracellular vesicles, the study seeks to uncover new insights into the relationship between alcohol use and metabolic dysregulation in this population.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals living with HIV who engage in at-risk alcohol consumption.
Not a fit: Patients who do not consume alcohol or those without HIV may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for managing metabolic health in individuals living with HIV who consume alcohol.
How similar studies have performed: Previous research has indicated that alcohol consumption negatively impacts insulin sensitivity, suggesting that this study builds on established findings in a novel context.
Where this research is happening
NEW ORLEANS, UNITED STATES
- LSU HEALTH SCIENCES CENTER — NEW ORLEANS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BOURGEOIS, BRIANNA LEILANI — LSU HEALTH SCIENCES CENTER
- Study coordinator: BOURGEOIS, BRIANNA LEILANI
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acquired Immune Deficiency Syndrome Virus, Acquired Immunodeficiency Syndrome Virus