How alcohol affects gut health and immune function
Alcohol and intestinal microvascular endothelium-immune axis and the role of gut derived immune nutrients
['FUNDING_R01'] · CLEVELAND CLINIC LERNER COM-CWRU · NIH-10897253
This study is looking at how drinking alcohol over a long time affects the good bacteria in your gut and your immune system, and it aims to find ways to help protect your gut health and immune responses when you drink.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | CLEVELAND CLINIC LERNER COM-CWRU (nih funded) |
| Locations | 1 site (CLEVELAND, UNITED STATES) |
| Trial ID | NIH-10897253 on ClinicalTrials.gov |
What this research studies
This research investigates the impact of chronic alcohol consumption on the gut microbiome and immune system. It focuses on how alcohol disrupts the intestinal barrier and alters the balance of gut bacteria, leading to inflammation and immune dysfunction. The study aims to understand the role of specific gut-derived nutrients, like butyrate, in maintaining gut health and immune responses in the context of alcohol exposure. By examining the interactions between gut cells and immune cells, the research seeks to identify potential therapeutic strategies to mitigate alcohol-induced damage.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults over 21 years old who consume alcohol regularly and may be experiencing related health issues.
Not a fit: Patients who do not consume alcohol or have no gastrointestinal or immune-related concerns may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve gut health and immune function in individuals affected by alcohol consumption.
How similar studies have performed: Previous research has shown promising results in understanding the gut-immune axis and the effects of dietary components on gut health, suggesting that this approach may yield valuable insights.
Where this research is happening
CLEVELAND, UNITED STATES
- CLEVELAND CLINIC LERNER COM-CWRU — CLEVELAND, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CRESCI, GAIL ANN — CLEVELAND CLINIC LERNER COM-CWRU
- Study coordinator: CRESCI, GAIL ANN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alcohol-Induced Disorders