How alcohol affects gut bacteria and immune response
Official title: The role of alcohol-associated microbiota membrane vesicles in mucosal immunity
Funded at University of Nebraska Medical Center · NIH-11061282 · Data updated 2026-11-12
This study looks at how drinking alcohol affects the good bacteria in your gut and the tiny particles they produce, which might make you more prone to infections and health problems, helping you understand how your drinking habits could impact your immune system and overall well-being.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Nebraska Medical Center NIH-funded |
| Lab location | 1 site (Omaha, United States) |
| Project start | April 28, 2023 |
| Project end | April 27, 2026 |
| Funding year | 2025 |
| Award (this year) | $81,724 |
| NIH project number | 5F32AA031180-03 |
| Project ID | NIH-11061282 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with a history of alcohol use disorder or those who consume alcohol regularly.
✕Less likely to help
Patients who do not consume alcohol or have no history of alcohol use disorder may not benefit from this research.
What this research studies
This research investigates how alcohol consumption alters the gut microbiota and its derived products, specifically focusing on membrane vesicles. These vesicles may play a significant role in increasing susceptibility to infections and tissue injury. By examining the composition and effects of these microbiota-derived vesicles, the study aims to uncover mechanisms that link alcohol use to various health issues. Patients may gain insights into how their alcohol consumption could impact their immune system and overall health.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and management of health risks associated with alcohol use disorder.
How similar studies have gone: Previous research has indicated that alterations in gut microbiota can influence health outcomes, suggesting that this approach may yield valuable insights.
Where this research is happening
-
University of Nebraska Medical Center
Omaha, United States Active
Researchers
- Principal investigator: Villageliu, Daniel — University of Nebraska Medical Center
- Study coordinator: Villageliu, Daniel
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.