How alcohol affects energy production in muscle cells
Official title: Alcohol-mediated mitochondrial adaptations in skeletal muscle: role of Sirtuin1
Funded at Lsu Health Sciences Center · NIH-11070967 · Data updated 2026-11-12
This study looks at how drinking alcohol affects the tiny powerhouses in your muscles that help produce energy, focusing on a special protein that keeps them healthy, to find better ways to help people with alcohol use problems who may be experiencing muscle issues.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Lsu Health Sciences Center NIH-funded |
| Lab location | 1 site (New Orleans, United States) |
| Project start | February 16, 2025 |
| Project end | August 15, 2026 |
| Funding year | 2024 |
| Award (this year) | $74,284 |
| NIH project number | 1F32AA031901-01A1 |
| Project ID | NIH-11070967 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who consume alcohol and experience muscle-related issues or have been diagnosed with alcohol use disorder.
✕Less likely to help
Patients who do not consume alcohol or do not have any muscle dysfunction related to alcohol use may not benefit from this research.
What this research studies
This research investigates how alcohol consumption impacts the function of mitochondria in skeletal muscle, which is crucial for energy production. The study focuses on the role of a protein called Sirtuin1, which is involved in regulating mitochondrial health and energy metabolism. By examining how alcohol alters mitochondrial function and contributes to muscle dysfunction, the research aims to uncover potential therapeutic targets for individuals with alcohol use disorder. Patients may benefit from insights that could lead to improved treatments for muscle-related issues caused by alcohol.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and treatment options for muscle dysfunction in individuals with alcohol use disorder.
How similar studies have gone: Previous research has shown promising results in understanding mitochondrial dysfunction related to alcohol, indicating that this approach has potential for significant findings.
Where this research is happening
-
Lsu Health Sciences Center
New Orleans, United States Active
Researchers
- Principal investigator: Rodriguez Graciani, Keishla Marie — Lsu Health Sciences Center
- Study coordinator: Rodriguez Graciani, Keishla Marie
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.