How alcohol affects brain changes related to aging and Alzheimer's disease
Noradrenergic mechanisms of alcohol's impact on the development of MCI and early stage AD
This study is looking at how drinking alcohol might affect brain health as we age, especially in relation to Alzheimer's disease and other types of dementia, to help understand how different drinking habits could impact memory and thinking in older adults.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project ID | NIH-10867264 on NIH RePORTER |
What this research studies
This research investigates the relationship between alcohol consumption and cognitive aging, particularly focusing on how alcohol misuse may accelerate the development of Alzheimer's disease (AD) and related dementias. The study examines the role of noradrenergic mechanisms in the brain, specifically looking at changes in the locus coeruleus, a critical area for cognitive function. By analyzing the effects of different levels of alcohol intake on brain health, the research aims to uncover the underlying biological processes that link alcohol use to cognitive decline in older adults.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults who consume varying amounts of alcohol and are at risk for cognitive decline or Alzheimer's disease.
Not a fit: Patients who do not consume alcohol or are not at risk for cognitive decline may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and prevention strategies for Alzheimer's disease and cognitive decline related to alcohol consumption.
How similar studies have performed: Previous studies have shown a connection between alcohol consumption and cognitive decline, suggesting that this research builds on established findings rather than exploring a completely novel area.
Where this research is happening
New Haven, United States
- Yale University — New Haven, United States (Active)
Researchers
- Principal investigator: Li, Chiang-Shan Ray — Yale University
- Study coordinator: Li, Chiang-Shan Ray
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.