How alcohol affects blood vessel health and disease progression
Official title: Biphasic Regulation of Endothelial Transdifferentiation by Alcohol and Its Impact on Vascular Disease
Funded at University of Rochester · NIH-10931494 · Data updated 2026-11-12
This study looks at how drinking alcohol in different amounts can affect your heart health by changing certain cells in your arteries, helping us understand both the good and bad effects of alcohol on conditions like arteriosclerosis, which can lead to heart attacks and strokes.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project start | September 20, 2023 |
| Project end | August 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $486,930 |
| NIH project number | 5R01AA031225-02 |
| Project ID | NIH-10931494 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with varying levels of alcohol consumption, particularly those at risk for cardiovascular diseases.
✕Less likely to help
Patients who do not consume alcohol or have no risk factors for cardiovascular disease may not benefit from this research.
What this research studies
This research investigates the complex relationship between alcohol consumption and cardiovascular disease, focusing on how different levels of alcohol intake can influence the transformation of endothelial cells into other cell types that contribute to artery thickening and disease. The study aims to understand the mechanisms behind both protective effects of moderate alcohol consumption and the harmful effects of heavy drinking. By examining how alcohol impacts arterial cells, the research seeks to uncover critical insights into the development of conditions like arteriosclerosis, which can lead to heart attacks and strokes.
Why it matters
Potential benefit: If successful, this research could lead to better prevention strategies and treatments for cardiovascular diseases related to alcohol consumption.
How similar studies have gone: Previous research has shown varying effects of alcohol on cardiovascular health, but this specific investigation into endothelial transdifferentiation is novel and untested.
Where this research is happening
-
University of Rochester
Rochester, United States Active
Researchers
- Principal investigator: Redmond, Eileen M. — University of Rochester
- Study coordinator: Redmond, Eileen M.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.