How alcohol affects a protein involved in liver disease
A-Kinase Anchoring Protein Dysregulation during Alcohol-Associated Liver Disease
['FUNDING_R01'] · CEDARS-SINAI MEDICAL CENTER · NIH-10897831
This study is looking at how a protein called AKAP12 is affected by drinking alcohol and how this might lead to liver problems, like fatty liver disease, so that we can find better ways to help people with alcohol-related liver issues.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | CEDARS-SINAI MEDICAL CENTER (nih funded) |
| Locations | 1 site (LOS ANGELES, UNITED STATES) |
| Trial ID | NIH-10897831 on ClinicalTrials.gov |
What this research studies
This research investigates the role of a protein called AKAP12 in the development of alcohol-associated liver disease (ALD). It examines how alcohol consumption alters the interactions of AKAP12 with other proteins that are crucial for liver function and lipid metabolism. By studying mouse models and human samples, the research aims to understand the mechanisms by which alcohol disrupts AKAP12's function, potentially leading to fatty liver and other liver-related issues. The findings could provide insights into new therapeutic targets for managing ALD.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a history of alcohol consumption who are experiencing liver issues, particularly those with fatty liver disease.
Not a fit: Patients who do not consume alcohol or have liver disease unrelated to alcohol may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that help prevent or mitigate liver damage in individuals with alcohol-associated liver disease.
How similar studies have performed: Other research has shown promising results in understanding the role of protein interactions in liver disease, suggesting that this approach could yield valuable insights.
Where this research is happening
LOS ANGELES, UNITED STATES
- CEDARS-SINAI MEDICAL CENTER — LOS ANGELES, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: RAMANI, KOMAL — CEDARS-SINAI MEDICAL CENTER
- Study coordinator: RAMANI, KOMAL
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.