How airway metabolites affect the risk of pneumonia
Official title: Airway metabolites shape susceptibility to pneumonia
Funded at Columbia University Health Sciences · NIH-11057670 · Data updated 2026-11-12
This study is looking at how certain substances in the airways affect the immune system's ability to fight off bacterial pneumonia, especially when it comes to balancing inflammation and protecting tissues, which could help develop better treatments for patients dealing with this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | April 1, 2024 |
| Project end | March 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $633,652 |
| NIH project number | 5R01HL170129-02 |
| Project ID | NIH-11057670 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals at high risk for pneumonia, particularly those with underlying respiratory conditions or compromised immune systems.
✕Less likely to help
Patients who do not have respiratory issues or are not at risk for pneumonia may not benefit from this research.
What this research studies
This research investigates how certain metabolites in the airways influence the body's immune response to bacterial pneumonia. It focuses on understanding the balance between inflammation needed to fight infections and the anti-inflammatory responses that protect tissues from damage. By studying the metabolites itaconate and fumarate, the research aims to uncover their roles in shaping immune cell behavior and their impact on the effectiveness of the immune response against antibiotic-resistant bacteria. Patients may benefit from insights that could lead to new treatments for pneumonia.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing and treating pneumonia caused by antibiotic-resistant bacteria.
How similar studies have gone: Other research has shown promise in understanding the role of metabolites in immune responses, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Columbia University Health Sciences
New York, United States Active
Researchers
- Principal investigator: Prince, Alice S — Columbia University Health Sciences
- Study coordinator: Prince, Alice S
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.