How airway irritants affect heart health in people with cardiovascular disease
Official title: Remodeled airway irritant reflexes as a cause of serious cardiovascular events
Funded at University of South Florida · NIH-10766125 · Data updated 2026-11-12
This study is looking at how air pollution can affect people with heart problems by triggering harmful reactions in their bodies, and it hopes to find better ways to help those at risk.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of South Florida NIH-funded |
| Lab location | 1 site (Tampa, United States) |
| Project start | January 26, 2021 |
| Project end | December 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $518,089 |
| NIH project number | 5R01HL152219-04 |
| Project ID | NIH-10766125 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with cardiovascular disease who may be affected by air pollution.
✕Less likely to help
Patients without cardiovascular disease or those who do not have any respiratory issues may not benefit from this research.
What this research studies
This research investigates how exposure to air pollutants and irritants can trigger harmful reflexes in individuals with cardiovascular disease (CVD). It aims to understand the mechanisms behind these reflexes, which can lead to serious cardiovascular events. By studying specific signaling pathways in animal models, the research seeks to identify the changes in reflex responses that occur in CVD patients compared to healthy individuals. The ultimate goal is to develop better clinical options for identifying and treating at-risk patients.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing acute cardiovascular events triggered by air pollution in patients with CVD.
How similar studies have gone: Previous research has shown that understanding the mechanisms of reflex responses to irritants can lead to significant advancements in treating cardiovascular conditions, indicating potential success for this approach.
Where this research is happening
-
University of South Florida
Tampa, United States Active
Researchers
- Principal investigator: Taylor-Clark, Thomas Edward — University of South Florida
- Study coordinator: Taylor-Clark, Thomas Edward
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.