How air pollution affects the immune response in children's lungs
PM exposure and changes in respiratory host defense responses
This study looks at how air pollution affects the immune system in children's lungs, helping us understand how being around dirty air can change how their bodies fight off infections, so we can find better ways to keep them healthy.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of North Carolina Chapel Hill NIH-funded |
| Lab location | 1 site (Chapel Hill, United States) |
| Project ID | NIH-10911874 on NIH RePORTER |
What this research studies
This research investigates the impact of particulate matter (PM) exposure on the immune responses of the respiratory system, particularly in children. It aims to understand how both acute and chronic exposure to air pollutants can alter the function of immune cells in the lungs, which are crucial for defending against infections. By analyzing samples collected during different levels of air pollution, the study seeks to uncover the mechanisms behind these changes and their implications for respiratory health. The findings could provide insights into how to protect vulnerable populations, especially children with developing immune systems.
Who could benefit from this research
Good fit: Ideal candidates for this research are children aged 0-11 years who may be exposed to varying levels of air pollution and are at risk for respiratory infections.
Not a fit: Patients who are not children or those without respiratory conditions may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for protecting children's respiratory health against the harmful effects of air pollution.
How similar studies have performed: Previous studies have shown associations between air pollution and respiratory health, but this research aims to explore novel mechanistic insights that have not been fully tested.
Where this research is happening
Chapel Hill, United States
- Univ of North Carolina Chapel Hill — Chapel Hill, United States (Active)
Researchers
- Principal investigator: Alexis, Neil — Univ of North Carolina Chapel Hill
- Study coordinator: Alexis, Neil
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.