How air pollution affects inflammation and heart health
Official title: Role of Splenic Pro-Resolving Mediators During Exposure to Particulate Air Pollution
Funded at University of Louisville · NIH-11035234 · Data updated 2026-11-12
This study is looking at how tiny particles in the air can affect inflammation and heart health, helping us understand how air pollution might increase the risk of heart disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Louisville NIH-funded |
| Lab location | 1 site (Louisville, United States) |
| Project start | May 1, 2023 |
| Project end | February 29, 2028 |
| Funding year | 2025 |
| Award (this year) | $568,103 |
| NIH project number | 5R01ES034389-03 |
| Project ID | NIH-11035234 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals exposed to high levels of air pollution, particularly those with existing cardiovascular conditions.
✕Less likely to help
Patients who live in areas with low air pollution or who do not have cardiovascular risk factors may not benefit from this research.
What this research studies
This research investigates the effects of exposure to fine particulate matter (PM2.5) on inflammation and cardiovascular health. It aims to understand how air pollution may disrupt the body's natural processes that resolve inflammation, which is crucial for preventing heart disease. By studying changes in the spleen and blood cells in response to PM exposure, the research seeks to uncover mechanisms that could lead to increased risks of atherosclerosis and other cardiovascular conditions. The findings could provide insights into how environmental factors contribute to heart health.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing cardiovascular diseases linked to air pollution.
How similar studies have gone: Previous research has shown that air pollution is a significant risk factor for cardiovascular diseases, indicating that this area of study is both relevant and critical.
Where this research is happening
-
University of Louisville
Louisville, United States Active
Researchers
- Principal investigator: Sansbury, Brian Edward — University of Louisville
- Study coordinator: Sansbury, Brian Edward
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.