How air pollution affects heart health through sleep patterns
(CIRCADIAN) Circadian Disruption as Mediator of Cardiometabolic Risk in Air Pollution
This study is looking at how air pollution affects heart health by disrupting our body's natural daily rhythms, and it's for anyone interested in understanding how breathing in dirty air might increase the risk of heart problems and diabetes.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Case Western Reserve University NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project ID | NIH-11112955 on NIH RePORTER |
What this research studies
This research investigates the impact of fine particulate matter air pollution on cardiovascular health by examining how it disrupts circadian rhythms. It aims to understand the mechanisms behind this disruption and its link to conditions like type 2 diabetes. The study will involve both animal models and human trials to explore the effects of air pollution exposure and identify potential pathways that contribute to cardiovascular risk. By leveraging existing clinical trials, the research seeks to develop personalized strategies to mitigate these health risks.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals living in areas with high levels of air pollution, particularly those at risk for cardiovascular diseases or metabolic disorders.
Not a fit: Patients who do not live in polluted environments or those without cardiovascular or metabolic health concerns may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for reducing cardiovascular disease risk associated with air pollution.
How similar studies have performed: Previous research has shown promising results in understanding the links between air pollution and cardiovascular health, making this approach both relevant and potentially impactful.
Where this research is happening
Cleveland, United States
- Case Western Reserve University — Cleveland, United States (Active)
Researchers
- Principal investigator: Rajagopalan, Sanjay — Case Western Reserve University
- Study coordinator: Rajagopalan, Sanjay
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.