How air pollution affects heart health through sleep patterns
(CIRCADIAN) Circadian Disruption as Mediator of Cardiometabolic Risk in Air Pollution
This study is looking at how air pollution, especially tiny particles in the air, affects heart health and sleep patterns, and it’s for people interested in understanding how these factors might lead to issues like diabetes and heart problems, with opportunities to take part in ways to improve their health.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Case Western Reserve University NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project ID | NIH-10906826 on NIH RePORTER |
What this research studies
This research investigates the impact of air pollution, specifically fine particulate matter (PM2.5), on cardiovascular health by examining how it disrupts circadian rhythms. The study aims to understand the mechanisms behind this disruption and its link to metabolic disorders like type 2 diabetes. By conducting both animal studies and human trials, the research will explore how exposure to air pollution can lead to insulin resistance and other cardiovascular risks. Patients may participate in interventions designed to mitigate these effects, contributing to a better understanding of personalized health strategies.
Who could benefit from this research
Good fit: Ideal candidates for participation include individuals living in areas with high levels of air pollution, particularly those with existing cardiovascular or metabolic conditions.
Not a fit: Patients who do not live in polluted environments or those without cardiovascular or metabolic disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for reducing cardiovascular risks associated with air pollution exposure.
How similar studies have performed: Previous research has shown promising results in understanding the links between air pollution and cardiovascular health, making this approach both relevant and potentially impactful.
Where this research is happening
Cleveland, United States
- Case Western Reserve University — Cleveland, United States (Active)
Researchers
- Principal investigator: Rajagopalan, Sanjay — Case Western Reserve University
- Study coordinator: Rajagopalan, Sanjay
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.