How air pollution affects heart and metabolic health
Interplay Between Macrophages, Lipid Oxidation and the Nrf2/HO-1 Axis in the Cardiometabolic Toxicity Induced by Ultrafine Particles
['FUNDING_R01'] · UNIVERSITY OF CALIFORNIA LOS ANGELES · NIH-11032867
This study is looking at how tiny particles in polluted air can harm your heart and metabolism by causing stress and inflammation in your body, especially through certain immune cells, to help us understand the serious health problems that can arise from breathing in dirty air.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA LOS ANGELES (nih funded) |
| Locations | 1 site (LOS ANGELES, UNITED STATES) |
| Trial ID | NIH-11032867 on ClinicalTrials.gov |
What this research studies
This research investigates the harmful effects of ultrafine particles from air pollution on cardiovascular and metabolic health. It focuses on how these particles lead to oxidative stress and inflammation, particularly through the action of immune cells called macrophages. By understanding the mechanisms involved, the research aims to uncover how exposure to air pollutants can cause serious health issues like atherosclerosis and liver problems. The study employs both experimental and epidemiological approaches to gather data on the impact of air pollution on human health.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals exposed to high levels of air pollution, particularly those with existing cardiovascular or metabolic conditions.
Not a fit: Patients who live in areas with low air pollution or those without cardiovascular or metabolic health issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better prevention strategies and treatments for cardiovascular diseases linked to air pollution.
How similar studies have performed: Previous research has shown significant links between air pollution and cardiovascular health, indicating that this approach is built on established findings.
Where this research is happening
LOS ANGELES, UNITED STATES
- UNIVERSITY OF CALIFORNIA LOS ANGELES — LOS ANGELES, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ARAUJO, JESUS ANTONIO — UNIVERSITY OF CALIFORNIA LOS ANGELES
- Study coordinator: ARAUJO, JESUS ANTONIO
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.