How air pollution affects heart and lung health in children
Air pollution disrupts Inflammasome Regulation in HEart And Lung Total Health (AIRHEALTH)
['FUNDING_P01'] · HARVARD SCHOOL OF PUBLIC HEALTH · NIH-11086429
This study looks at how air pollution from cars and forest fires affects the heart and lungs of children, aiming to understand how it causes inflammation in their bodies and find ways to help protect their health.
Quick facts
| Phase | ['FUNDING_P01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | HARVARD SCHOOL OF PUBLIC HEALTH (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-11086429 on ClinicalTrials.gov |
What this research studies
This research investigates the impact of air pollution, particularly from automobile exhaust and forest fires, on heart and lung health in children. It focuses on understanding how exposure to pollutants triggers inflammation in the body, specifically through a protein called interleukin-1 beta (IL-1β). By examining the mechanisms of this inflammatory response, the research aims to identify potential therapies that could mitigate the harmful effects of air pollution on cardiopulmonary health. The study employs a systems biology approach to explore various pathways involved in this process.
Who could benefit from this research
Good fit: Ideal candidates for this research are children aged 0-11 years who are exposed to air pollution and may suffer from related respiratory or cardiovascular conditions.
Not a fit: Patients who are not children or who do not have any exposure to air pollution may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments and public health policies that protect children from the harmful effects of air pollution on their heart and lung health.
How similar studies have performed: Previous research has shown success in understanding the inflammatory responses related to air pollution, making this study a continuation of established findings.
Where this research is happening
BOSTON, UNITED STATES
- HARVARD SCHOOL OF PUBLIC HEALTH — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: NADEAU, KARI C. — HARVARD SCHOOL OF PUBLIC HEALTH
- Study coordinator: NADEAU, KARI C.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.