How air pollution affects Alzheimer's disease and its genetic interactions
Neurotoxicity of particulate matter and its interaction with APOE in neurodegeneration
This study is looking at how air pollution might affect the development and worsening of Alzheimer's disease in older adults, hoping to find ways to better prevent and treat the condition.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California-Irvine NIH-funded |
| Lab location | 1 site (Irvine, United States) |
| Project ID | NIH-10590465 on NIH RePORTER |
What this research studies
This research investigates the impact of air pollution, specifically particulate matter, on the development and progression of Alzheimer's disease (AD) in elderly individuals. It aims to understand how environmental factors, particularly toxic air constituents, interact with genetic risk factors to influence neurodegeneration. By examining these gene-environment interactions, the study seeks to uncover the mechanisms through which air pollution may contribute to the onset of AD. Patients may benefit from insights that could lead to improved prevention strategies and treatments for Alzheimer's disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are elderly individuals, particularly those with a genetic predisposition to Alzheimer's disease.
Not a fit: Patients who are not elderly or do not have a genetic risk for Alzheimer's disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and prevention strategies for Alzheimer's disease linked to air pollution exposure.
How similar studies have performed: Other studies have shown promising results in understanding the relationship between environmental factors and Alzheimer's disease, indicating that this approach has potential for significant findings.
Where this research is happening
Irvine, United States
- University of California-Irvine — Irvine, United States (Active)
Researchers
- Principal investigator: Kitazawa, Masashi — University of California-Irvine
- Study coordinator: Kitazawa, Masashi
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.