How AIM2 affects intestinal stem cell development during inflammation
Official title: Impact of AIM2 on Intestinal Stem Cell Differentiation During Inflammation
Funded at University of Arizona · NIH-11019657 · Data updated 2026-11-12
This study is looking at how a gene called AIM2 helps gut stem cells develop, especially when there’s inflammation, to better understand how gut bacteria and immune cells work together, which could lead to new ways to manage conditions like inflammatory bowel disease (IBD).
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Arizona NIH-funded |
| Lab location | 1 site (Tucson, United States) |
| Project start | January 1, 2025 |
| Project end | November 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $567,205 |
| NIH project number | 1R01DK141491-01 |
| Project ID | NIH-11019657 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with inflammatory bowel diseases such as Crohn's disease or ulcerative colitis.
✕Less likely to help
Patients without inflammatory bowel diseases or those with unrelated gastrointestinal conditions may not benefit from this research.
What this research studies
This research investigates the role of the AIM2 gene in the differentiation of intestinal stem cells, particularly during inflammatory conditions. It focuses on understanding how interactions between gut microbes, epithelial cells, and immune cells influence intestinal health and disease. By using animal models, the research aims to uncover the mechanisms by which AIM2 contributes to the regulation of inflammation in the gut, which is crucial for conditions like inflammatory bowel disease (IBD). The findings could lead to new insights into how to better manage or treat chronic inflammatory diseases.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for patients suffering from inflammatory bowel diseases.
How similar studies have gone: Previous research has shown that targeting similar pathways in animal models can lead to significant advancements in understanding and treating inflammatory bowel diseases.
Where this research is happening
-
University of Arizona
Tucson, United States Active
Researchers
- Principal investigator: Wilson, Justin Ethan — University of Arizona
- Study coordinator: Wilson, Justin Ethan
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.