How aging tissue stiffness affects cancer progression
Characterization of relation between tissue viscoelasticity and tumor progression in aging tissues
This study is looking at how the stiffness of aging skin might affect the growth of skin cancer in older adults, and it aims to find out how these changes in skin tissue could help tumors develop.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Nevada Las Vegas NIH-funded |
| Lab location | 1 site (Las Vegas, United States) |
| Project ID | NIH-10906110 on NIH RePORTER |
What this research studies
This research investigates how the mechanical properties of aging tissues, particularly their stiffness, influence the progression of skin cancer in elderly patients. By measuring the elastic modulus and relaxation time of skin tissues from individuals of different ages, the study aims to understand the relationship between tissue mechanics and tumor development. The researchers will also create an in vitro model to explore the mechanisms by which these mechanical changes may promote cancer progression, particularly focusing on pathways involving the p53 protein.
Who could benefit from this research
Good fit: Ideal candidates for this research are elderly patients with skin cancer or those at high risk for developing skin cancer due to aging.
Not a fit: Patients who are younger and do not have any history of skin cancer or related conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating skin cancer in older adults by targeting the mechanical properties of tissues.
How similar studies have performed: While there is emerging evidence regarding the role of tissue mechanics in cancer progression, this specific approach focusing on aging tissues and their mechanical properties is relatively novel.
Where this research is happening
Las Vegas, United States
- University of Nevada Las Vegas — Las Vegas, United States (Active)
Researchers
- Principal investigator: Park, Seungman — University of Nevada Las Vegas
- Study coordinator: Park, Seungman
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.