How aging tissue environments influence cancer development in blood cells
Aged tissue environments as drivers of oncogenic adaptation in hematopoiesis
This study looks at how getting older can change the environment where blood cells grow, especially how inflammation might raise the chances of developing cancers like leukemia, and it aims to find ways to help reduce this risk for older adults.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado Denver NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project ID | NIH-10766136 on NIH RePORTER |
What this research studies
This research investigates how the aging process affects the environment of blood cells, particularly focusing on how inflammation in older individuals can lead to an increased risk of cancers like leukemia. By studying changes in the bone marrow of elderly patients, the researchers aim to understand how these changes promote the selection of harmful mutations in blood cell progenitors. The study utilizes mouse models to explore the relationship between inflammation and cancer development, with the goal of identifying potential interventions to reduce cancer risk in older adults.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults, particularly those over the age of 50, who may be at increased risk for blood cancers.
Not a fit: Patients who are younger than 50 or those without any risk factors for blood cancers may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing leukemia and other cancers in older adults by targeting inflammation.
How similar studies have performed: Previous studies have shown that targeting inflammation can reduce cancer risk, suggesting that this approach may be promising.
Where this research is happening
Aurora, UNITED STATES
- University of Colorado Denver — Aurora, United States (Active)
Researchers
- Principal investigator: Degregori, James V — University of Colorado Denver
- Study coordinator: Degregori, James V
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.