How aging fat tissue affects the body's response to severe infections
Role of adipose tissue inflammaging and metabolic dysfunction during sepsis
['FUNDING_R01'] · UNIVERSITY OF MINNESOTA · NIH-10994138
This study is looking into why older adults are more likely to get seriously ill from infections, focusing on how changes in their body fat might affect their immune response, and it aims to help us understand how to better protect older people from sepsis.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF MINNESOTA (nih funded) |
| Locations | 1 site (MINNEAPOLIS, UNITED STATES) |
| Trial ID | NIH-10994138 on ClinicalTrials.gov |
What this research studies
This research investigates why older adults are more susceptible to sepsis, a severe response to infection. It focuses on the role of visceral white adipose tissue (vWAT), which undergoes changes with age that may lead to increased inflammation and metabolic dysfunction. By studying immune cells in aged fat tissue, the research aims to understand how these changes contribute to the heightened risk of sepsis in older individuals. The approach includes examining the signaling pathways that regulate fat metabolism and inflammation during sepsis.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults, particularly those over 65, who are at a higher risk for sepsis.
Not a fit: Patients under 65 or those without risk factors for sepsis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments and preventive strategies for sepsis in older adults.
How similar studies have performed: Previous research has indicated that targeting inflammation and metabolic dysfunction in older adults can improve outcomes in similar conditions, suggesting a promising avenue for this investigation.
Where this research is happening
MINNEAPOLIS, UNITED STATES
- UNIVERSITY OF MINNESOTA — MINNEAPOLIS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CAMELL, CHRISTINA — UNIVERSITY OF MINNESOTA
- Study coordinator: CAMELL, CHRISTINA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.