How aging changes in bone marrow affect acute myeloid leukemia
Impact of the senescent bone marrow microenvironment in AML biology
This work looks at whether aging-related changes in the bone marrow help leukemia grow in older adults with AML.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Temple Univ of the Commonwealth NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-11264870 on NIH RePORTER |
What this research studies
This project examines bone marrow support cells (called mesenchymal stromal cells) from people with AML to see how aging and cellular senescence alter the marrow environment. Researchers will compare molecular and epigenetic signs of aging in cells from older versus younger patients and use laboratory models to test how those changes influence leukemia cell behavior. The team will also test ways to reverse or block the aging features in the marrow that appear to support leukemia growth. The goal is to find targets that could make the bone marrow less supportive of AML and guide development of new treatments.
Who could benefit from this research
Good fit: Adults with acute myeloid leukemia, particularly older adults (for example those over about 55 or around the typical median age of 70), are the most relevant group for this research.
Not a fit: People without AML or whose disease is driven solely by genetic factors unrelated to the bone marrow environment may not receive direct benefit from this work.
Why it matters
Potential benefit: If successful, the work could reveal new targets to make the bone marrow less friendly to leukemia and improve outcomes for older AML patients.
How similar studies have performed: Preclinical research suggests the marrow environment and senescent cells can influence AML and that targeting senescence shows promise in lab models, but clinical benefit in patients has not yet been proven.
Where this research is happening
Philadelphia, United States
- Temple Univ of the Commonwealth — Philadelphia, United States (Active)
Researchers
- Principal investigator: Abdul-Aziz, Amina — Temple Univ of the Commonwealth
- Study coordinator: Abdul-Aziz, Amina
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.