How aging changes cells and RNA in MDS and AML
Cellular Heterogeneity and Aging in MDS and AML
['FUNDING_OTHER'] · VA EASTERN COLORADO HEALTH CARE SYSTEM · NIH-11131012
This project looks at how aging changes RNA processing in blood cancers to find markers that predict disease progression and treatment resistance for people with MDS or AML.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | VA EASTERN COLORADO HEALTH CARE SYSTEM (nih funded) |
| Locations | 1 site (Aurora, UNITED STATES) |
| Trial ID | NIH-11131012 on ClinicalTrials.gov |
What this research studies
Researchers will use new sequencing methods that read full-length mRNA in individual cells from people with MDS and AML to capture differences in RNA processing. They will analyze primary patient blood and bone marrow samples at single-cell resolution to link RNA processing patterns with age, disease progression, and drug resistance. The work combines detailed molecular profiling with clinical information about how patients responded to treatments. Results aim to identify RNA-based signatures that could help doctors choose better uses of existing therapies.
Who could benefit from this research
Good fit: People diagnosed with myelodysplastic syndrome (MDS) or acute myeloid leukemia (AML), especially older adults and Veterans who can provide bone marrow or blood samples, are the ideal candidates.
Not a fit: People without MDS or AML, or patients who cannot provide samples or clinical follow-up, are unlikely to receive direct benefit from this project.
Why it matters
Potential benefit: If successful, this work could help doctors predict who will respond to current treatments and guide more personalized therapy to reduce drug resistance.
How similar studies have performed: Single-cell sequencing and RNA processing studies have shown promise in cancer, but using full-length mRNA processing profiles to predict age-related progression and drug resistance in MDS/AML is a relatively new approach.
Where this research is happening
Aurora, UNITED STATES
- VA EASTERN COLORADO HEALTH CARE SYSTEM — Aurora, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: GILLEN, AUSTIN E — VA EASTERN COLORADO HEALTH CARE SYSTEM
- Study coordinator: GILLEN, AUSTIN E
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.