How aging cells in the body affect brain health
Systemic Cell Senescence as a Mediator of Brain Aging Through Circulation
This study is looking at how proteins from older cells in the blood might affect brain health as we age, and it’s testing whether getting rid of these old cells can help improve brain function and reduce inflammation, which could lead to new ways to keep our minds sharp as we get older.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project ID | NIH-11032837 on NIH RePORTER |
What this research studies
This research investigates how certain proteins from aging cells in the bloodstream contribute to brain aging and cognitive decline. By studying mouse models, the researchers aim to understand if removing these aging cells can improve brain health and reduce inflammation. The approach involves exchanging blood between young and old mice to observe changes in brain function. This could lead to new strategies for preventing age-related cognitive issues.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults experiencing early signs of cognitive decline or those concerned about age-related brain health.
Not a fit: Patients with acute neurological conditions unrelated to aging may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that slow down or prevent cognitive decline in aging individuals.
How similar studies have performed: Previous research has shown promising results in understanding the role of aging cells in other tissues, suggesting potential for success in this area as well.
Where this research is happening
Rochester, United States
- Mayo Clinic Rochester — Rochester, United States (Active)
Researchers
- Principal investigator: Schafer, Marissa Joy — Mayo Clinic Rochester
- Study coordinator: Schafer, Marissa Joy
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.