How aging brain cells contribute to Alzheimer's disease
The pathogenic effects of senescent cells on their microenvironments and their role in human brain aging
This study is looking at how aging cells in the brain might play a role in Alzheimer's and related dementias, hoping to find new ways to help treat these conditions by understanding the changes these cells cause.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Hlth Science Center NIH-funded |
| Lab location | 1 site (San Antonio, United States) |
| Project ID | NIH-10933770 on NIH RePORTER |
What this research studies
This research investigates the role of senescent cells, which are aging cells that can negatively affect their surroundings, in the development of Alzheimer's Disease and Related Dementias (ADRD). By analyzing brain samples from individuals with ADRD and using advanced machine learning techniques, the study aims to identify specific molecular changes associated with these senescent neurons. The goal is to understand how these cells contribute to brain aging and neuronal death, potentially leading to new therapeutic strategies. Patients may benefit from insights that could inform future treatments targeting cellular senescence in Alzheimer's.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Alzheimer's disease or related dementias.
Not a fit: Patients with early-stage cognitive impairment not related to Alzheimer's or other forms of dementia may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that slow down or prevent the progression of Alzheimer's disease.
How similar studies have performed: Previous research has shown promising results linking cellular senescence to neurodegeneration, suggesting that this approach could yield significant insights.
Where this research is happening
San Antonio, United States
- University of Texas Hlth Science Center — San Antonio, United States (Active)
Researchers
- Principal investigator: Zare, Habil — University of Texas Hlth Science Center
- Study coordinator: Zare, Habil
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.