How aging and senescent cells change immune memory in tissues
Effect of aging and senescent cells
['FUNDING_P01'] · UNIVERSITY OF MINNESOTA · NIH-11319007
This project looks at how getting older and build-up of senescent cells change tissue immune memory cells in adults and older people.
Quick facts
| Phase | ['FUNDING_P01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF MINNESOTA (nih funded) |
| Locations | 1 site (MINNEAPOLIS, UNITED STATES) |
| Trial ID | NIH-11319007 on ClinicalTrials.gov |
What this research studies
From a patient's perspective, researchers will collect blood and tissue samples from adults and use advanced single-cell tests to read the behavior of tissue-resident memory T cells. They will compare results between younger and older donors and use mouse models to test the effects of removing senescent cells. The team will separate the impact of the organism's age versus the age of individual T cells to find what drives immune decline. Results will guide ideas for restoring stronger local immunity in aging tissues.
Who could benefit from this research
Good fit: Ideal candidates are adults aged 21 and older, especially older adults willing to donate blood or tissue samples or participate in immune-focused research at the University of Minnesota.
Not a fit: Children under 21 and people who cannot provide blood or tissue samples would not be direct participants and are unlikely to benefit from this specific project.
Why it matters
Potential benefit: If successful, this work could point to treatments that restore local immune function in older adults and lower their risk of infections or poor vaccine responses.
How similar studies have performed: Some animal studies show that removing senescent cells can improve immune responses, but applying this to human tissue-resident memory T cells is relatively new.
Where this research is happening
MINNEAPOLIS, UNITED STATES
- UNIVERSITY OF MINNESOTA — MINNEAPOLIS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MASOPUST, DAVID — UNIVERSITY OF MINNESOTA
- Study coordinator: MASOPUST, DAVID
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.