How aging and inflammation affect outcomes in severe lung disease
Official title: The Association Between Aging, Inflammation, and Clinical Outcomes in Acute Respiratory Distress Syndrome
Funded at University of Maryland Baltimore · NIH-10906138 · Data updated 2026-11-12
This study is looking at how aging and inflammation affect the severity of Acute Respiratory Distress Syndrome (ARDS) in older adults, with the goal of finding better treatments that fit each person's unique health profile.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Maryland Baltimore NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | August 15, 2023 |
| Project end | April 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $154,500 |
| NIH project number | 5R03AG082798-02 |
| Project ID | NIH-10906138 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are older adults diagnosed with Acute Respiratory Distress Syndrome.
✕Less likely to help
Patients who are younger and do not have ARDS may not receive any benefit from this research.
What this research studies
This research investigates the relationship between aging, inflammation, and clinical outcomes in patients suffering from Acute Respiratory Distress Syndrome (ARDS). It focuses on understanding how biological age and inflammatory responses impact the severity of ARDS, particularly in older adults. The study will analyze protein biomarkers and explore different subphenotypes of ARDS to identify potential new treatment approaches. By examining these factors, the research aims to improve patient outcomes and tailor therapies based on individual biological profiles.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for older patients with ARDS, potentially improving survival rates and quality of life.
How similar studies have gone: Previous research has shown promising results in understanding the role of inflammation and aging in various diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Maryland Baltimore
Baltimore, United States Active
Researchers
- Principal investigator: Levine, Andrea — University of Maryland Baltimore
- Study coordinator: Levine, Andrea
Related research
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This project looks at why some ARDS survivors have ongoing weakness and how immune, hormone, and muscle energy factors might influence recovery.</n>
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Understanding why some people with severe lung injury get worse and how to tailor therapy
A patient-focused program that looks at why people develop sepsis-associated ARDS and how their bodies respond, with the goal of guiding better, personalized treatments.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.