How aging and exercise affect waste clearance in the brain of healthy and diabetic individuals
Aging and Exercise Effects of Dural Lymphatic Clearance in Healthy Human and Diabetic Brains
This study is looking at how aging and exercise affect the brain's ability to clear out waste, especially in people over 65 and those with diabetes, to find ways to keep our brains healthy as we get older.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project ID | NIH-11212182 on NIH RePORTER |
What this research studies
This research investigates the relationship between aging, exercise, and the clearance of waste products from the brain, particularly in individuals with diabetes and those over 65 years old. It explores how the glymphatic system, which helps remove toxins from the brain, may function differently in these populations. The study will involve monitoring brain waste clearance during various physical activities and sleep patterns to understand how these factors influence cognitive health. By examining both healthy individuals and those with diabetes, the research aims to uncover potential interventions to improve brain health.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals aged 65 and older, particularly those with type-2 diabetes or at risk for Alzheimer's disease.
Not a fit: Patients under the age of 65 or those without diabetes or cognitive impairment may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or slowing the progression of Alzheimer's disease in older adults and those with diabetes.
How similar studies have performed: Previous research has shown promising results regarding the role of exercise in enhancing glymphatic clearance in animal models, suggesting potential applicability to human populations.
Where this research is happening
La Jolla, United States
- University of California, San Diego — La Jolla, United States (Active)
Researchers
- Principal investigator: Miyazaki, Mitsue — University of California, San Diego
- Study coordinator: Miyazaki, Mitsue
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.