How aging and beta-amyloid affect cognitive function in twins at midlife
Contribution of child development, biological aging, and beta-amyloid to cognitive function of the Louisville twins at midlife
This study is looking at how aging affects brain health in middle-aged twins, checking if faster biological aging leads to more beta-amyloid buildup and memory issues, so we can better understand these changes in people aged 40 to 64.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Southern California NIH-funded |
| Lab location | 1 site (Los Angeles, UNITED STATES) |
| Project ID | NIH-10626142 on NIH RePORTER |
What this research studies
This research investigates the relationship between biological aging, beta-amyloid levels, and cognitive function in midlife individuals, specifically focusing on twins from the Louisville Twin Study. By studying 750 twins aged 40-64, the researchers will assess cognitive abilities and collect blood samples to measure biological age and beta-amyloid levels. The study aims to determine if accelerated biological aging leads to higher beta-amyloid accumulation and subsequent cognitive decline. This unique approach leverages extensive childhood data to explore these associations.
Who could benefit from this research
Good fit: Ideal candidates for this research are twins aged 40-64 who have participated in the Louisville Twin Study.
Not a fit: Patients who are not twins or those outside the age range of 40-64 may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and early identification of cognitive decline and Alzheimer's disease in midlife individuals.
How similar studies have performed: Previous studies have shown promising results in understanding cognitive decline through similar longitudinal twin approaches, indicating potential for success in this research.
Where this research is happening
Los Angeles, UNITED STATES
- University of Southern California — Los Angeles, United States (Active)
Researchers
- Principal investigator: Beam, Christopher Ryan — University of Southern California
- Study coordinator: Beam, Christopher Ryan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.