How aging and Alzheimer's disease affect brain immune cells
Official title: Regulation of Microglial Function by Major Histocompatibility Complex I in Aging and Alzheimer's Disease
Funded at University of Oklahoma Hlth Sciences Ctr · NIH-10901383 · Data updated 2026-11-12
This study is looking at how brain immune cells called microglia change as we age and how they might help or hurt our brains in Alzheimer's disease, with the goal of finding new ways to support brain health as we get older.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Oklahoma Hlth Sciences Ctr NIH-funded |
| Lab location | 1 site (Oklahoma City, United States) |
| Project start | July 1, 2024 |
| Project end | June 30, 2028 |
| Funding year | 2024 |
| Award (this year) | $44,477 |
| NIH project number | 1F30AG087705-01 |
| Project ID | NIH-10901383 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are older adults experiencing cognitive decline or diagnosed with Alzheimer's disease.
✕Less likely to help
Patients with early-stage Alzheimer's or those without any cognitive impairment may not benefit from this research.
What this research studies
This research investigates the role of microglia, the brain's immune cells, in aging and Alzheimer's disease. It focuses on how these cells change with age and how they may initially protect the brain but can become harmful as Alzheimer's progresses. The study examines specific genes and receptors that microglia express, which could help regulate their activity and potentially improve brain health. By understanding these mechanisms, the research aims to identify new therapeutic targets for age-related cognitive decline.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that enhance brain health and function in aging individuals and those with Alzheimer's disease.
How similar studies have gone: Other research has shown promising results in understanding microglial function in aging and Alzheimer's, indicating that this approach could lead to significant advancements.
Where this research is happening
-
University of Oklahoma Hlth Sciences Ctr
Oklahoma City, United States Active
Researchers
- Principal investigator: Kellogg, Collyn Michael — University of Oklahoma Hlth Sciences Ctr
- Study coordinator: Kellogg, Collyn Michael
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.