How aging and Alzheimer's change brain connections
Interactive Effects of Aging and AD on Brain Networks
['FUNDING_R01'] · STANFORD UNIVERSITY · NIH-11306643
This project uses advanced MRI scans to see how normal aging and Alzheimer's disease together change brain wiring in older adults.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | STANFORD UNIVERSITY (nih funded) |
| Locations | 1 site (STANFORD, UNITED STATES) |
| Trial ID | NIH-11306643 on ClinicalTrials.gov |
What this research studies
You would be part of a study comparing older adults with and without Alzheimer's using new MRI methods that can see tiny brain structures and their connections. Researchers will look at neurite (nerve fiber) structure and whole-brain network organization to find patterns linked to aging and Alzheimer’s changes. The team will combine microstructural imaging and connectome analyses to find which brain regions become most vulnerable as people age. Results aim to explain why some areas decline faster and could point to earlier signs of Alzheimer’s.
Who could benefit from this research
Good fit: Ideal candidates are adults aged 65 and older, including people with Alzheimer's dementia and age-matched older adults without dementia who can undergo MRI scans.
Not a fit: People under 65, those with non-Alzheimer's brain disorders, or anyone who cannot have an MRI (for example because of certain metal implants or severe claustrophobia) may not benefit from participating.
Why it matters
Potential benefit: If successful, this work could help detect Alzheimer's changes earlier and point to ways to protect vulnerable brain connections.
How similar studies have performed: Prior MRI and connectome studies show that aging and Alzheimer's alter brain networks, but applying advanced neurite-level MRI in humans is relatively new.
Where this research is happening
STANFORD, UNITED STATES
- STANFORD UNIVERSITY — STANFORD, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: HOSSEINI, HADI — STANFORD UNIVERSITY
- Study coordinator: HOSSEINI, HADI
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.