How aging affects vaccine responses in B cells
Impact of aging on human B cell vaccine responses
This study is looking at how getting older affects the way our immune system responds to vaccines, especially focusing on B cells that help make antibodies, to find out why older adults might not respond as well to vaccines and how we can make them work better for them.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California-Irvine NIH-funded |
| Lab location | 1 site (Irvine, United States) |
| Project ID | NIH-11084398 on NIH RePORTER |
What this research studies
This research investigates how aging impacts the immune response to vaccines, particularly focusing on B cells, which are crucial for producing antibodies. The study aims to identify specific age-related changes in B cells that may hinder their ability to respond effectively to vaccines. By using advanced techniques, including a novel human tonsil organoid model, researchers will explore the mechanisms behind B cell dysfunction in older adults. The goal is to better understand these changes over time and improve vaccine efficacy in the aging population.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults aged 65 and older who may experience diminished vaccine responses due to aging.
Not a fit: Patients under the age of 65 or those with pre-existing conditions that severely compromise their immune systems may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved vaccine strategies for older adults, enhancing their immune responses and overall health.
How similar studies have performed: Previous research has shown promising results in understanding immune responses in aging, but this specific focus on B cells and their role in vaccine responses is relatively novel.
Where this research is happening
Irvine, United States
- University of California-Irvine — Irvine, United States (Active)
Researchers
- Principal investigator: Nicholas, Dequina Angelina — University of California-Irvine
- Study coordinator: Nicholas, Dequina Angelina
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.