How aging affects the toughness of bones and potential treatments
Proteoglycans and age-related deterioration of bone toughness
['FUNDING_R01'] · UNIVERSITY OF TEXAS SAN ANTONIO · NIH-10644016
This study is looking at how changes in bone structure as we age can make bones weaker and more likely to break, and it aims to find ways to improve bone strength using special substances that could help keep bones healthy, especially for older adults.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF TEXAS SAN ANTONIO (nih funded) |
| Locations | 1 site (SAN ANTONIO, UNITED STATES) |
| Trial ID | NIH-10644016 on ClinicalTrials.gov |
What this research studies
This research investigates how age-related changes in bone composition, particularly the role of proteoglycans, affect bone toughness and the risk of fractures. The study aims to understand the mechanisms behind bone dehydration and its impact on bone health. By exploring the potential of delivering glycosaminoglycans to improve bone toughness, the research seeks to develop new therapeutic strategies for preventing fractures in older adults. Patients may be involved in trials assessing the effectiveness of these treatments.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults experiencing age-related bone loss or those at risk of fractures.
Not a fit: Patients with acute bone injuries or those not experiencing age-related bone deterioration may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that enhance bone toughness and reduce fracture risk in older adults.
How similar studies have performed: Previous research has shown promising results in improving bone health through similar approaches, indicating potential for success in this area.
Where this research is happening
SAN ANTONIO, UNITED STATES
- UNIVERSITY OF TEXAS SAN ANTONIO — SAN ANTONIO, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: WANG, XIAODU — UNIVERSITY OF TEXAS SAN ANTONIO
- Study coordinator: WANG, XIAODU
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.