How aging affects the regulation of protein production in cells
Molecular mechanisms of translational regulation in aging
['FUNDING_R01'] · BOSTON UNIVERSITY MEDICAL CAMPUS · NIH-10552685
This study is looking at how aging affects the way our cells make proteins, using yeast to see how diet and genetics play a role, with the hope of finding ways to promote healthier aging and longer life.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BOSTON UNIVERSITY MEDICAL CAMPUS (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-10552685 on ClinicalTrials.gov |
What this research studies
This research investigates how the efficiency of protein production changes as organisms age, focusing on the role of specific proteins that bind to mRNA. By using yeast as a model organism, the study aims to understand how dietary restrictions and genetic changes can influence these processes. Researchers will employ advanced techniques like RNA sequencing and ribosome profiling to analyze how these factors affect gene expression and protein levels in aging cells. The goal is to uncover the molecular mechanisms that contribute to increased longevity and cellular health.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals interested in the biological mechanisms of aging and those who may benefit from interventions aimed at improving health during aging.
Not a fit: Patients with acute or severe age-related diseases that do not involve the molecular mechanisms of aging may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for promoting healthy aging and longevity in humans.
How similar studies have performed: Previous research has shown promising results in understanding aging through genetic and dietary interventions, suggesting that this approach could yield valuable insights.
Where this research is happening
BOSTON, UNITED STATES
- BOSTON UNIVERSITY MEDICAL CAMPUS — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LABUNSKYY, VYACHESLAV M — BOSTON UNIVERSITY MEDICAL CAMPUS
- Study coordinator: LABUNSKYY, VYACHESLAV M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancers