How aging affects the mechanics of the bladder
The interplay between active and passive mechanics in the aging bladder
['FUNDING_R21'] · UNIVERSITY OF COLORADO · NIH-10827248
This study is looking at how getting older affects the bladder's strength and function, especially how the bladder's muscle cells work with their surroundings, to help find better ways to treat common bladder issues like urinary retention in older adults.
Quick facts
| Phase | ['FUNDING_R21'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF COLORADO (nih funded) |
| Locations | 1 site (Boulder, UNITED STATES) |
| Trial ID | NIH-10827248 on ClinicalTrials.gov |
What this research studies
This research investigates how the aging process alters the mechanical properties of the bladder, particularly focusing on the interactions between smooth muscle cells and the surrounding extracellular matrix. By using advanced techniques like optogenetics and multiphoton microscopy, the researchers aim to develop new methods to test bladder mechanics in a laboratory setting. The goal is to better understand the causes of lower urinary tract symptoms, such as urinary retention, which are common in older adults. This work could lead to improved treatments for bladder dysfunction associated with aging.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults aged 21 and older who experience lower urinary tract symptoms.
Not a fit: Patients who are younger than 21 or do not experience any urinary tract symptoms may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that alleviate lower urinary tract symptoms in older adults.
How similar studies have performed: Previous research has shown promising results in understanding bladder mechanics, but this specific approach using optogenetics and advanced microscopy is relatively novel.
Where this research is happening
Boulder, UNITED STATES
- UNIVERSITY OF COLORADO — Boulder, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CALVE, SARAH — UNIVERSITY OF COLORADO
- Study coordinator: CALVE, SARAH
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.