How aging affects the mechanics of elastic arteries
Official title: Multiscale Effects of Aging on Elastic Arterial Tissue Mechanics
Funded at University of Connecticut Storrs · NIH-10993151 · Data updated 2026-11-12
This study looks at how getting older affects a protein called elastin in our blood vessels, which can make them stiffer and lead to heart problems, helping us understand more about how aging impacts heart health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Connecticut Storrs NIH-funded |
| Lab location | 1 site (Storrs-Mansfield, United States) |
| Project start | December 1, 2023 |
| Project end | November 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $546,981 |
| NIH project number | 5R01AG084715-02 |
| Project ID | NIH-10993151 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are older adults experiencing cardiovascular issues or those at risk for age-related vascular diseases.
✕Less likely to help
Patients who are younger and do not have any cardiovascular risk factors may not receive benefit from this research.
What this research studies
This research investigates the impact of aging on the mechanical properties of elastin in arterial tissues. By using advanced molecular modeling and experimental techniques, the study aims to uncover how structural changes in elastin contribute to arterial stiffness and related health issues as people age. The research will explore the molecular mechanisms behind these changes, potentially leading to new insights into age-related vascular diseases. Patients may benefit from a better understanding of how aging affects their cardiovascular health.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing or treating age-related vascular diseases.
How similar studies have gone: Previous research has shown promising results in understanding the mechanics of elastin and its role in vascular health, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Connecticut Storrs
Storrs-Mansfield, United States Active
Researchers
- Principal investigator: Tarakanova, Anna — University of Connecticut Storrs
- Study coordinator: Tarakanova, Anna
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.