How aging affects the mechanics of blood vessel cells
Endothelial biomechanics in vascular aging
['FUNDING_OTHER'] · UNIVERSITY OF ILLINOIS AT CHICAGO · NIH-10804883
This study looks at how the cells lining our blood vessels change as we get older, focusing on certain proteins that might affect blood flow, and it aims to help us understand and improve heart health for older adults.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF ILLINOIS AT CHICAGO (nih funded) |
| Locations | 1 site (Chicago, UNITED STATES) |
| Trial ID | NIH-10804883 on ClinicalTrials.gov |
What this research studies
This research investigates how the mechanics of endothelial cells, which line blood vessels, change as we age. It focuses on understanding the role of specific proteins, such as CD36 and Caveolin-1, in causing these changes and how they contribute to conditions like endothelial dysfunction. By studying both young and older mice, the researchers aim to identify the molecular mechanisms behind age-related stiffening of blood vessels and the impact of lipid composition on this process. The findings could lead to better understanding and potential treatments for vascular issues in older adults.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults, particularly those experiencing vascular issues or related health concerns.
Not a fit: Patients who are younger or do not have any vascular health issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for vascular diseases associated with aging, enhancing the quality of life for older adults.
How similar studies have performed: Previous research has shown promising results in understanding endothelial mechanics and their implications for vascular health, suggesting that this approach could yield valuable insights.
Where this research is happening
Chicago, UNITED STATES
- UNIVERSITY OF ILLINOIS AT CHICAGO — Chicago, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LEVITAN, IRENA — UNIVERSITY OF ILLINOIS AT CHICAGO
- Study coordinator: LEVITAN, IRENA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.