How aging affects the mechanics of blood vessel cells
Official title: Endothelial biomechanics in vascular aging
Funded at University of Illinois at Chicago · NIH-10804883 · Data updated 2026-11-12
This study looks at how the cells lining our blood vessels change as we get older, focusing on certain proteins that might affect blood flow, and it aims to help us understand and improve heart health for older adults.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Illinois at Chicago NIH-funded |
| Lab location | 1 site (Chicago, UNITED STATES) |
| Project start | July 1, 2023 |
| Project end | June 30, 2025 |
| Funding year | 2023 |
| Award (this year) | $327,795 |
| NIH project number | 1R56AG082099-01 |
| Project ID | NIH-10804883 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are older adults, particularly those experiencing vascular issues or related health concerns.
✕Less likely to help
Patients who are younger or do not have any vascular health issues may not benefit from this research.
What this research studies
This research investigates how the mechanics of endothelial cells, which line blood vessels, change as we age. It focuses on understanding the role of specific proteins, such as CD36 and Caveolin-1, in causing these changes and how they contribute to conditions like endothelial dysfunction. By studying both young and older mice, the researchers aim to identify the molecular mechanisms behind age-related stiffening of blood vessels and the impact of lipid composition on this process. The findings could lead to better understanding and potential treatments for vascular issues in older adults.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for vascular diseases associated with aging, enhancing the quality of life for older adults.
How similar studies have gone: Previous research has shown promising results in understanding endothelial mechanics and their implications for vascular health, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Illinois at Chicago
Chicago, United States Active
Researchers
- Principal investigator: Levitan, Irena — University of Illinois at Chicago
- Study coordinator: Levitan, Irena
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.