How aging affects the development of osteoarthritis
Official title: Systemic contribution of age-associated epigenetic mechanisms to osteoarthritis
Funded at Hebrew Rehabilitation Center for Aged · NIH-10465071 · Data updated 2026-11-12
This study is looking at how getting older might affect the way our genes work and how that could lead to osteoarthritis, with the goal of finding new ways to treat the condition, especially in joints like your hands, knees, and hips.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Hebrew Rehabilitation Center for Aged NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | September 9, 2019 |
| Project end | June 30, 2025 |
| Funding year | 2022 |
| Award (this year) | $425,515 |
| NIH project number | 5R01AR075356-04 |
| Project ID | NIH-10465071 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are older adults experiencing symptoms of osteoarthritis, particularly in the hands, knees, or hips.
✕Less likely to help
Patients who are younger and do not have symptoms of osteoarthritis may not benefit from this research.
What this research studies
This research investigates the connection between aging and osteoarthritis (OA), focusing on how age-related changes in gene expression may contribute to the disease. By examining epigenetic modifications in immune blood cells, the study aims to uncover new biological mechanisms that could lead to innovative treatment targets for OA. The research will analyze data from a well-characterized cohort to assess the impact of these changes on the severity of OA in commonly affected joints like the hands, knees, and hips.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic targets for osteoarthritis, improving treatment options for patients.
How similar studies have gone: Previous research has shown promise in understanding the role of epigenetics in various diseases, suggesting that this approach could yield valuable insights into osteoarthritis.
Where this research is happening
-
Hebrew Rehabilitation Center for Aged
Boston, United States Active
Researchers
- Principal investigator: Yau, Michelle Szu-Huei — Hebrew Rehabilitation Center for Aged
- Study coordinator: Yau, Michelle Szu-Huei
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.