How aging affects the brain's response after cardiac arrest
Official title: Aging-associated changes in the brain's response after a cardiac arrest
Funded at University of Colorado Denver · NIH-10984378 · Data updated 2026-11-12
This study looks at how brain damage happens after a heart stops beating, especially how this affects older people differently, using mice to learn about the brain's response and memory changes.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado Denver NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project start | August 15, 2024 |
| Project end | July 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $224,424 |
| NIH project number | 1K08NS135129-01A1 |
| Project ID | NIH-10984378 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research are older adults who have experienced cardiac arrest or are at risk of it.
✕Less likely to help
Patients who are younger than 21 years old or those without a history of cardiac arrest may not receive benefit from this research.
What this research studies
This research investigates the molecular mechanisms that lead to brain injury following cardiac arrest, particularly focusing on how these mechanisms differ with age. The study utilizes mouse models to analyze neuronal cell death pathways, brain inflammation, and cognitive function. By understanding these processes, the research aims to identify why older individuals experience worse neurological outcomes after cardiac arrest. The project is supported by experienced mentors in the fields of cardiac arrest and aging research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments and care strategies for older patients who suffer cardiac arrest.
How similar studies have gone: Previous research has shown promising results in understanding brain injury mechanisms in younger populations, but this specific focus on aging and cardiac arrest is relatively novel.
Where this research is happening
-
University of Colorado Denver
Aurora, United States Active
Researchers
- Principal investigator: Basak, Jacob — University of Colorado Denver
- Study coordinator: Basak, Jacob
Related research
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Aging and brain injury after cardiac arrest: how age changes brain response
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.