How aging affects the body's ability to manage pain in osteoarthritis.
Age-related decline in endogenous pain modulation and its impact on osteoarthritis pain
This study looks at how getting older affects the way our bodies manage pain, especially for those with osteoarthritis, by comparing younger and older rats to find out how their brains handle pain differently, which could help improve pain relief for older adults with this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Maryland Baltimore NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-11054598 on NIH RePORTER |
What this research studies
This research investigates how aging impacts the body's natural pain modulation mechanisms, particularly in relation to osteoarthritis pain. It focuses on understanding the brain networks involved in pain inhibition and how these networks change with age. By studying both young and older rats, the research aims to uncover the links between dysfunctional pain modulation and chronic pain conditions, specifically osteoarthritis, which is common in older adults. The findings could lead to better pain management strategies for older patients suffering from osteoarthritis.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults experiencing osteoarthritis pain.
Not a fit: Patients who are younger than 21 or do not have osteoarthritis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved pain management techniques for older adults suffering from osteoarthritis.
How similar studies have performed: Previous studies have shown promising results in understanding pain modulation in aging, suggesting that this research builds on established findings.
Where this research is happening
Baltimore, United States
- University of Maryland Baltimore — Baltimore, United States (Active)
Researchers
- Principal investigator: Ro, Jin Y — University of Maryland Baltimore
- Study coordinator: Ro, Jin Y
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.