How aging affects the ability of stem cells to regenerate bone
Official title: Role of LINC-mediated Mechanosignaling in MSC Aging
Funded at Boise State University · NIH-10829798 · Data updated 2026-11-12
This study looks at how getting older and spending a lot of time in bed affects special cells in your bone marrow that help with healing and regeneration, and it aims to find ways to keep these cells healthy so they can better support bone recovery.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boise State University NIH-funded |
| Lab location | 1 site (Boise, United States) |
| Project start | March 1, 2020 |
| Project end | January 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $280,231 |
| NIH project number | 5R01AG059923-05 |
| Project ID | NIH-10829798 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include older adults or individuals who have experienced prolonged bedrest and are at risk for bone health issues.
✕Less likely to help
Patients who are younger and have no history of bone health issues or prolonged inactivity may not benefit from this research.
What this research studies
This research investigates how aging and prolonged bedrest impact the health and regenerative capacity of mesenchymal stem cells (MSCs) found in bone marrow. It focuses on the role of mechanical signaling pathways that connect the cell's cytoskeleton to its nucleus, which are crucial for maintaining MSC function. By understanding these mechanisms, the research aims to identify why MSCs lose their ability to proliferate and differentiate as we age or during periods of inactivity. This knowledge could lead to new strategies for enhancing bone regeneration and improving patient outcomes.
Why it matters
Potential benefit: If successful, this research could lead to improved therapies for osteoporosis and enhanced healing processes in aging patients.
How similar studies have gone: Other research has shown promising results in understanding the role of mechanical signaling in stem cell function, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Boise State University
Boise, United States Active
Researchers
- Principal investigator: Uzer, Gunes — Boise State University
- Study coordinator: Uzer, Gunes
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.