How aging affects older adults' response to resistance training
Official title: The Impact of Biological Mechanisms of Aging on Response Variability to Resistance Training in Older Adults (BRIO)
Funded at Mayo Clinic Rochester · NIH-10979394 · Data updated 2026-11-12
This study is looking at how aging affects older adults' responses to strength training, helping us understand why some people over 65 get more benefits from exercise than others, so we can tailor fitness programs to fit their needs better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project start | September 1, 2024 |
| Project end | August 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $1,294,013 |
| NIH project number | 1R01AG089150-01 |
| Project ID | NIH-10979394 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are older adults aged 65 and above who are interested in improving their physical health through resistance training.
✕Less likely to help
Patients who are younger than 65 years old or those with severe mobility limitations may not benefit from this research.
What this research studies
This research investigates how biological mechanisms of aging influence the varying responses of older adults to resistance training. It focuses on understanding the role of cellular senescence and epigenetic changes in physical function and insulin sensitivity among individuals aged 65 and older. By analyzing these biological factors, the study aims to identify why some older adults benefit more from exercise than others. Participants may undergo assessments related to their physical capabilities and metabolic health in relation to their exercise routines.
Why it matters
Potential benefit: If successful, this research could lead to personalized exercise programs that enhance physical function and metabolic health in older adults.
How similar studies have gone: Previous research has shown that understanding biological factors can significantly improve exercise outcomes in older populations, indicating a promising avenue for this study.
Where this research is happening
-
Mayo Clinic Rochester
Rochester, United States Active
Researchers
- Principal investigator: Lebrasseur, Nathan K — Mayo Clinic Rochester
- Study coordinator: Lebrasseur, Nathan K
Related research
Other NIH-funded projects on the same topics.
-
Aging Well with HIV: Alcohol, Risk Reduction, and Education Center (AWAR3E)
A center at Yale is exploring how aging with HIV interacts with alcohol use to create inflammation and frailty, with the goal of finding biomarkers and potential treatments.
-
Cognitive SuperAging: Exploring why some octogenarians stay sharp in memory
This NIH grant studies why a small group of people aged 80+ keep memory skills as good as much younger people, hoping to understand how to protect memory as we age.
-
Biological aging across the lifespan through a national high school-to-adult study
This grant uses a long-running national study of students and adults to collect saliva biomarkers of aging, alongside surveys, to understand how aging markers relate to health and life experiences.
-
Understanding how aging and Alzheimer’s affect how people make tough choices
This NIH grant studies how aging and Alzheimer’s risk change how people decide between immediate and delayed rewards and risky options, with the goal of helping older adults stay financially and healthwise safer.
-
Understanding how brain resilience and multiple brain pathologies influence aging and Alzheimer's disease
A long-term study follows older adults to learn how resilience to brain changes helps reduce dementia risk and what biological factors are linked to better cognitive aging.
-
National Neighborhood Data Archive helps researchers study aging health in U.S. neighborhoods
A nationwide data resource will help researchers understand how where people live affects health and aging, with a focus on respiratory illnesses in older adults.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.