How aging affects older adults' response to resistance training
The Impact of Biological Mechanisms of Aging on Response Variability to Resistance Training in Older Adults (BRIO)
This study is looking at how aging affects older adults' responses to strength training, helping us understand why some people over 65 get more benefits from exercise than others, so we can tailor fitness programs to fit their needs better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project ID | NIH-10979394 on NIH RePORTER |
What this research studies
This research investigates how biological mechanisms of aging influence the varying responses of older adults to resistance training. It focuses on understanding the role of cellular senescence and epigenetic changes in physical function and insulin sensitivity among individuals aged 65 and older. By analyzing these biological factors, the study aims to identify why some older adults benefit more from exercise than others. Participants may undergo assessments related to their physical capabilities and metabolic health in relation to their exercise routines.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults aged 65 and above who are interested in improving their physical health through resistance training.
Not a fit: Patients who are younger than 65 years old or those with severe mobility limitations may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to personalized exercise programs that enhance physical function and metabolic health in older adults.
How similar studies have performed: Previous research has shown that understanding biological factors can significantly improve exercise outcomes in older populations, indicating a promising avenue for this study.
Where this research is happening
Rochester, United States
- Mayo Clinic Rochester — Rochester, United States (Active)
Researchers
- Principal investigator: Lebrasseur, Nathan K — Mayo Clinic Rochester
- Study coordinator: Lebrasseur, Nathan K
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.