How aging affects neutrophils and stroke recovery
Aging Exacerbates Neutrophil Persistence and Negatively Impacts Stroke Outcomes
This study is looking at how a type of immune cell called neutrophils affects recovery after a stroke, especially in older adults, to see if understanding their behavior can help improve healing for those who have had a stroke.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Northwestern University at Chicago NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project ID | NIH-10864541 on NIH RePORTER |
What this research studies
This research investigates the role of neutrophils, a type of immune cell, in the recovery process after ischemic stroke, particularly in older adults. It aims to understand how aging influences the persistence of these cells in the brain following a stroke and how this impacts recovery outcomes. By analyzing gene expression data, the study focuses on a specific transcription factor, Nr4a2, which may play a critical role in neutrophil behavior in the context of stroke. The findings could lead to new therapeutic strategies to improve recovery for older stroke patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults who have experienced an ischemic stroke.
Not a fit: Patients who are younger or have not experienced a stroke may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved recovery strategies for older adults who suffer from strokes.
How similar studies have performed: Other research has shown promising results in understanding the role of immune cells in stroke recovery, suggesting that this approach could yield valuable insights.
Where this research is happening
Chicago, United States
- Northwestern University at Chicago — Chicago, United States (Active)
Researchers
- Principal investigator: Batra, Ayush — Northwestern University at Chicago
- Study coordinator: Batra, Ayush
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.